A Partial History of Lost Causes

In St. Petersburg, Russia, world chess champion Aleksandr Bezetov begins a quixotic quest: He launches a dissident presidential campaign against Vladimir Putin. He knows he will not win—and that he is risking his life in the process—but a deeper conviction propels him forward.
 
In Cambridge, Massachusetts, thirty-year-old English lecturer Irina Ellison struggles for a sense of purpose. Irina is certain she has inherited Huntington’s disease—the same cruel illness that ended her father’s life. When Irina finds an old, photocopied letter her father wrote to the young Aleksandr Bezetov, she makes a fateful decision. Her father asked the chess prodigy a profound question—How does one proceed in a lost cause?—but never received an adequate reply. Leaving everything behind, Irina travels to Russia to find Bezetov and get an answer for her father, and for herself.